violetFluor™ 500 Anti-Mouse CD4 (RM4-5)
The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations including Th17 and T regulatory (Treg) cells, as well as on dendritic cells.
The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will compete for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells.
| Name | violetFluor™ 500 Anti-Mouse CD4 (RM4-5) | |
|---|---|---|
| Cat. No. | 85-0042 | |
| Alternative Names | L3T4, T4 | |
| Gene ID | 12504 | |
| Clone | RM4-5 | |
| Isotype | Rat IgG2a, Îş | |
| Reactivity | Mouse | |
| Format | violetFluor™ 500 | |
| Application |
|
Original: $84.00
-70%$84.00
$25.20violetFluor™ 500 Anti-Mouse CD4 (RM4-5)
The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations including Th17 and T regulatory (Treg) cells, as well as on dendritic cells.
The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will compete for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells.
| Name | violetFluor™ 500 Anti-Mouse CD4 (RM4-5) | |
|---|---|---|
| Cat. No. | 85-0042 | |
| Alternative Names | L3T4, T4 | |
| Gene ID | 12504 | |
| Clone | RM4-5 | |
| Isotype | Rat IgG2a, Îş | |
| Reactivity | Mouse | |
| Format | violetFluor™ 500 | |
| Application |
|
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Description
The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations including Th17 and T regulatory (Treg) cells, as well as on dendritic cells.
The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will compete for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells.
| Name | violetFluor™ 500 Anti-Mouse CD4 (RM4-5) | |
|---|---|---|
| Cat. No. | 85-0042 | |
| Alternative Names | L3T4, T4 | |
| Gene ID | 12504 | |
| Clone | RM4-5 | |
| Isotype | Rat IgG2a, Îş | |
| Reactivity | Mouse | |
| Format | violetFluor™ 500 | |
| Application |
|
