APC Anti-Human CD154 (CD40L) (5C8)
The 5C8 antibody reacts with human CD154 which is also known as CD40L (CD40 ligand). CD154 is a 39kDa member of the TNF-α superfamily and is predominantly expressed on activated T cells but is also expressed on NK cells, mast cells, basophils, and eosinophils. CD154 binds to CD40, a molecule that is expressed on antigen presenting cells including B cells, monocytes/macrophages, and dendritic cells. The interaction of CD154 and CD40 regulates the activation of antigen presenting cells and is critical for B cell costimulation. The 5C8 antibody has been reported to block CD40L-CD40 interactions.
| Name | APC Anti-Human CD154 (CD40L) (5C8) |
|---|---|
| Cat. No. | 20-1547 |
| Alternative Names | CD40L, gp39, T-BAM, TRAP, Ly-62 |
| Gene ID | 959 |
| Clone | 5C8 |
| Isotype | Mouse IgG2a, κ |
| Reactivity | Human |
| Cross Reactivity | rhesus monkey, cynomolgus monkey |
| Format | APC |
| Application | Flow Cytometry |
APC Anti-Human CD154 (CD40L) (5C8)
The 5C8 antibody reacts with human CD154 which is also known as CD40L (CD40 ligand). CD154 is a 39kDa member of the TNF-α superfamily and is predominantly expressed on activated T cells but is also expressed on NK cells, mast cells, basophils, and eosinophils. CD154 binds to CD40, a molecule that is expressed on antigen presenting cells including B cells, monocytes/macrophages, and dendritic cells. The interaction of CD154 and CD40 regulates the activation of antigen presenting cells and is critical for B cell costimulation. The 5C8 antibody has been reported to block CD40L-CD40 interactions.
| Name | APC Anti-Human CD154 (CD40L) (5C8) |
|---|---|
| Cat. No. | 20-1547 |
| Alternative Names | CD40L, gp39, T-BAM, TRAP, Ly-62 |
| Gene ID | 959 |
| Clone | 5C8 |
| Isotype | Mouse IgG2a, κ |
| Reactivity | Human |
| Cross Reactivity | rhesus monkey, cynomolgus monkey |
| Format | APC |
| Application | Flow Cytometry |
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Product Information
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Description
The 5C8 antibody reacts with human CD154 which is also known as CD40L (CD40 ligand). CD154 is a 39kDa member of the TNF-α superfamily and is predominantly expressed on activated T cells but is also expressed on NK cells, mast cells, basophils, and eosinophils. CD154 binds to CD40, a molecule that is expressed on antigen presenting cells including B cells, monocytes/macrophages, and dendritic cells. The interaction of CD154 and CD40 regulates the activation of antigen presenting cells and is critical for B cell costimulation. The 5C8 antibody has been reported to block CD40L-CD40 interactions.
| Name | APC Anti-Human CD154 (CD40L) (5C8) |
|---|---|
| Cat. No. | 20-1547 |
| Alternative Names | CD40L, gp39, T-BAM, TRAP, Ly-62 |
| Gene ID | 959 |
| Clone | 5C8 |
| Isotype | Mouse IgG2a, κ |
| Reactivity | Human |
| Cross Reactivity | rhesus monkey, cynomolgus monkey |
| Format | APC |
| Application | Flow Cytometry |
