violetFluor™ 500 Anti-Human CD3 (UCHT1)
The UCHT1 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex. Together with CD3 gamma, CD3 delta and CD3 zeta, CD3 epsilon assembles to form the CD3 complex that associates with the T cell receptor (TCR). Along with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte development and on all mature T cells.
The UCHT1 antibody is a widely used phenotypic marker for human T cells. In addition, binding/cross-linking of UCHT1 antibody to CD3e can induce cell activation (use format suitable for functional assays).
| Name | violetFluor™ 500 Anti-Human CD3 (UCHT1) | |
|---|---|---|
| Cat. No. | 85-0038 | |
| Alternative Names | Leu-4, T3 | |
| Gene ID | 915 | |
| Clone | UCHT1 | |
| Isotype | Mouse IgG1, kappa | |
| Reactivity | Human | |
| Cross Reactivity | Chimpanzee | |
| Format | violetFluor™ 500 | |
| Application |
|
violetFluor™ 500 Anti-Human CD3 (UCHT1)
The UCHT1 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex. Together with CD3 gamma, CD3 delta and CD3 zeta, CD3 epsilon assembles to form the CD3 complex that associates with the T cell receptor (TCR). Along with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte development and on all mature T cells.
The UCHT1 antibody is a widely used phenotypic marker for human T cells. In addition, binding/cross-linking of UCHT1 antibody to CD3e can induce cell activation (use format suitable for functional assays).
| Name | violetFluor™ 500 Anti-Human CD3 (UCHT1) | |
|---|---|---|
| Cat. No. | 85-0038 | |
| Alternative Names | Leu-4, T3 | |
| Gene ID | 915 | |
| Clone | UCHT1 | |
| Isotype | Mouse IgG1, kappa | |
| Reactivity | Human | |
| Cross Reactivity | Chimpanzee | |
| Format | violetFluor™ 500 | |
| Application |
|
Product Information
Product Information
Shipping & Returns
Shipping & Returns
Description
The UCHT1 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex. Together with CD3 gamma, CD3 delta and CD3 zeta, CD3 epsilon assembles to form the CD3 complex that associates with the T cell receptor (TCR). Along with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte development and on all mature T cells.
The UCHT1 antibody is a widely used phenotypic marker for human T cells. In addition, binding/cross-linking of UCHT1 antibody to CD3e can induce cell activation (use format suitable for functional assays).
| Name | violetFluor™ 500 Anti-Human CD3 (UCHT1) | |
|---|---|---|
| Cat. No. | 85-0038 | |
| Alternative Names | Leu-4, T3 | |
| Gene ID | 915 | |
| Clone | UCHT1 | |
| Isotype | Mouse IgG1, kappa | |
| Reactivity | Human | |
| Cross Reactivity | Chimpanzee | |
| Format | violetFluor™ 500 | |
| Application |
|
