violetFluor™ 450 Anti-Mouse CD279 (PD-1) (RMP1-30)
The RMP1-30 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein member of the Ig superfamily of molecules. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells.
| Name | violetFluor™ 450 Anti-Mouse CD279 (PD-1) (RMP1-30) |
|---|---|
| Cat. No. | 75-9981 |
| Gene ID | 18566 |
| Clone | RMP1-30 |
| Isotype | Rat IgG2b, κ |
| Reactivity | Mouse |
| Format | violetFluor™ 450 |
| Application | Flow Cytometry |
violetFluor™ 450 Anti-Mouse CD279 (PD-1) (RMP1-30)
The RMP1-30 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein member of the Ig superfamily of molecules. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells.
| Name | violetFluor™ 450 Anti-Mouse CD279 (PD-1) (RMP1-30) |
|---|---|
| Cat. No. | 75-9981 |
| Gene ID | 18566 |
| Clone | RMP1-30 |
| Isotype | Rat IgG2b, κ |
| Reactivity | Mouse |
| Format | violetFluor™ 450 |
| Application | Flow Cytometry |
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Product Information
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Description
The RMP1-30 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein member of the Ig superfamily of molecules. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells.
| Name | violetFluor™ 450 Anti-Mouse CD279 (PD-1) (RMP1-30) |
|---|---|
| Cat. No. | 75-9981 |
| Gene ID | 18566 |
| Clone | RMP1-30 |
| Isotype | Rat IgG2b, κ |
| Reactivity | Mouse |
| Format | violetFluor™ 450 |
| Application | Flow Cytometry |
