PerCP-Cyanine5.5 Anti-Mouse TCR beta (H57-597)
The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.
The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.
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Recent Citations:
Fu Z, Dean JW, Xiong L, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021 Jul 22;12(1):4462. doi: 10.1038/s41467-021-24755-9. PMID: 34294718.
| Name | PerCP-Cyanine5.5 Anti-Mouse TCR beta (H57-597) |
|---|---|
| Cat. No. | 65-5961 |
| Alternative Names | TCRb, TCRbeta, TCR-b chain, TCR-b, b-TCR |
| Gene ID | 21577 |
| Clone | H57-597 |
| Isotype | Armenian Hamster IgG |
| Reactivity | Mouse |
| Format | PerCP-Cyanine5.5 |
| Application | Flow Cytometry |
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PerCP-Cyanine5.5 Anti-Mouse TCR beta (H57-597)
The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.
The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.
Â
Recent Citations:
Fu Z, Dean JW, Xiong L, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021 Jul 22;12(1):4462. doi: 10.1038/s41467-021-24755-9. PMID: 34294718.
| Name | PerCP-Cyanine5.5 Anti-Mouse TCR beta (H57-597) |
|---|---|
| Cat. No. | 65-5961 |
| Alternative Names | TCRb, TCRbeta, TCR-b chain, TCR-b, b-TCR |
| Gene ID | 21577 |
| Clone | H57-597 |
| Isotype | Armenian Hamster IgG |
| Reactivity | Mouse |
| Format | PerCP-Cyanine5.5 |
| Application | Flow Cytometry |
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Description
The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.
The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.
Â
Recent Citations:
Fu Z, Dean JW, Xiong L, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021 Jul 22;12(1):4462. doi: 10.1038/s41467-021-24755-9. PMID: 34294718.
| Name | PerCP-Cyanine5.5 Anti-Mouse TCR beta (H57-597) |
|---|---|
| Cat. No. | 65-5961 |
| Alternative Names | TCRb, TCRbeta, TCR-b chain, TCR-b, b-TCR |
| Gene ID | 21577 |
| Clone | H57-597 |
| Isotype | Armenian Hamster IgG |
| Reactivity | Mouse |
| Format | PerCP-Cyanine5.5 |
| Application | Flow Cytometry |
