PerCP-Cyanine5.5 Anti-Mouse CD11a (M17/4)
The M17/4 monoclonal antibody reacts with mouse CD11a, an 180kD glycoprotein that is also known as integrin alpha L (ITGAL). CD11a associates non-covalently with CD18 (integrein beta 2) to form the lymphocyte function associated antigen-1 (LFA-1) heterodimer. CD11a is expressed on the cell surface of all leukocytes. LFA-1 plays a critical role in intercellular adhesion that is mediated through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). LFA-1 also functions in lymphocyte costimulatory signaling. On resting cells, LFA-1 exists in a low-affinity conformation that is rapidly induced to the high-affinity conformation following cell stimulation.
| Name | PerCP-Cyanine5.5 Anti-Mouse CD11a (M17/4) |
|---|---|
| Cat. No. | 65-0111 |
| Alternative Names | alpha L integrin α. CD11 antigen-like family member A. integrin αalpha-L. leukocyte adhesion glycoprotein LFA-1 alpha chain. leukocyte function-associated molecule 1 alpha chain. lymphocyte antigen 15. lymphocyte function associated antigen 1, alpha polypeptide |
| Gene ID | 16408 |
| Clone | M17/4 |
| Isotype | Rat IgG2a, kappa |
| Reactivity | Mouse |
| Format | PerCP-Cyanine5.5 |
| Application | Flow Cytometry |
PerCP-Cyanine5.5 Anti-Mouse CD11a (M17/4)
The M17/4 monoclonal antibody reacts with mouse CD11a, an 180kD glycoprotein that is also known as integrin alpha L (ITGAL). CD11a associates non-covalently with CD18 (integrein beta 2) to form the lymphocyte function associated antigen-1 (LFA-1) heterodimer. CD11a is expressed on the cell surface of all leukocytes. LFA-1 plays a critical role in intercellular adhesion that is mediated through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). LFA-1 also functions in lymphocyte costimulatory signaling. On resting cells, LFA-1 exists in a low-affinity conformation that is rapidly induced to the high-affinity conformation following cell stimulation.
| Name | PerCP-Cyanine5.5 Anti-Mouse CD11a (M17/4) |
|---|---|
| Cat. No. | 65-0111 |
| Alternative Names | alpha L integrin α. CD11 antigen-like family member A. integrin αalpha-L. leukocyte adhesion glycoprotein LFA-1 alpha chain. leukocyte function-associated molecule 1 alpha chain. lymphocyte antigen 15. lymphocyte function associated antigen 1, alpha polypeptide |
| Gene ID | 16408 |
| Clone | M17/4 |
| Isotype | Rat IgG2a, kappa |
| Reactivity | Mouse |
| Format | PerCP-Cyanine5.5 |
| Application | Flow Cytometry |
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Product Information
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Description
The M17/4 monoclonal antibody reacts with mouse CD11a, an 180kD glycoprotein that is also known as integrin alpha L (ITGAL). CD11a associates non-covalently with CD18 (integrein beta 2) to form the lymphocyte function associated antigen-1 (LFA-1) heterodimer. CD11a is expressed on the cell surface of all leukocytes. LFA-1 plays a critical role in intercellular adhesion that is mediated through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). LFA-1 also functions in lymphocyte costimulatory signaling. On resting cells, LFA-1 exists in a low-affinity conformation that is rapidly induced to the high-affinity conformation following cell stimulation.
| Name | PerCP-Cyanine5.5 Anti-Mouse CD11a (M17/4) |
|---|---|
| Cat. No. | 65-0111 |
| Alternative Names | alpha L integrin α. CD11 antigen-like family member A. integrin αalpha-L. leukocyte adhesion glycoprotein LFA-1 alpha chain. leukocyte function-associated molecule 1 alpha chain. lymphocyte antigen 15. lymphocyte function associated antigen 1, alpha polypeptide |
| Gene ID | 16408 |
| Clone | M17/4 |
| Isotype | Rat IgG2a, kappa |
| Reactivity | Mouse |
| Format | PerCP-Cyanine5.5 |
| Application | Flow Cytometry |
