PE Anti-Mouse CD117 (c-Kit) (ACK2)
The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of ≥≥immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of ≥≥the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of ≥≥c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.
The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo (use format appropriate for functional assays).
| Name | PE Anti-Mouse CD117 (c-Kit) (ACK2) |
|---|---|
| Cat. No. | 50-1172 |
| Alternative Names | Steel Factor Receptor, SCFR, cKit |
| Gene ID | 16590 |
| Clone | ACK2 |
| Isotype | Rat IgG2b, κ |
| Reactivity | Mouse |
| Cross Reactivity | Rat |
| Format | PE |
| Application | Flow Cytometry |
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PE Anti-Mouse CD117 (c-Kit) (ACK2)
The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of ≥≥immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of ≥≥the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of ≥≥c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.
The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo (use format appropriate for functional assays).
| Name | PE Anti-Mouse CD117 (c-Kit) (ACK2) |
|---|---|
| Cat. No. | 50-1172 |
| Alternative Names | Steel Factor Receptor, SCFR, cKit |
| Gene ID | 16590 |
| Clone | ACK2 |
| Isotype | Rat IgG2b, κ |
| Reactivity | Mouse |
| Cross Reactivity | Rat |
| Format | PE |
| Application | Flow Cytometry |
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Description
The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of ≥≥immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of ≥≥the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of ≥≥c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.
The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo (use format appropriate for functional assays).
| Name | PE Anti-Mouse CD117 (c-Kit) (ACK2) |
|---|---|
| Cat. No. | 50-1172 |
| Alternative Names | Steel Factor Receptor, SCFR, cKit |
| Gene ID | 16590 |
| Clone | ACK2 |
| Isotype | Rat IgG2b, κ |
| Reactivity | Mouse |
| Cross Reactivity | Rat |
| Format | PE |
| Application | Flow Cytometry |
