APC Anti-Mouse CD80 (B7-1) (16-10A1)
The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
Recent Publications:
Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790. (Flow Cytometry)
| Name | APC Anti-Mouse CD80 (B7-1) (16-10A1) |
|---|---|
| Cat. No. | 20-0801 |
| Alternative Names | B7, Ly-53 |
| Gene ID | 12519 |
| Clone | 16-10A1 |
| Isotype | Armenian Hamster IgG |
| Reactivity | Mouse |
| Format | APC |
| Application | Flow Cytometry |
APC Anti-Mouse CD80 (B7-1) (16-10A1)
The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
Recent Publications:
Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790. (Flow Cytometry)
| Name | APC Anti-Mouse CD80 (B7-1) (16-10A1) |
|---|---|
| Cat. No. | 20-0801 |
| Alternative Names | B7, Ly-53 |
| Gene ID | 12519 |
| Clone | 16-10A1 |
| Isotype | Armenian Hamster IgG |
| Reactivity | Mouse |
| Format | APC |
| Application | Flow Cytometry |
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Description
The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
Recent Publications:
Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790. (Flow Cytometry)
| Name | APC Anti-Mouse CD80 (B7-1) (16-10A1) |
|---|---|
| Cat. No. | 20-0801 |
| Alternative Names | B7, Ly-53 |
| Gene ID | 12519 |
| Clone | 16-10A1 |
| Isotype | Armenian Hamster IgG |
| Reactivity | Mouse |
| Format | APC |
| Application | Flow Cytometry |
