PE anti-rat TSPAN8
Tetraspanins, also referred to as the transmembrane 4 superfamily (TM4SF) proteins, have four transmembrane alpha-helices and two extracellular domains. It acts as molecular facilitators forming a web between themselves and a multitude of molecules. It is also involved in adhesion, motility, matrix modulation and cell fusion. Tetraspanins/Tetraspanin-complexes are constitutive components of exosomes. During exosome assembly, Tetraspanins become internalized via a tyrosine-based internalization motif. Internalized membrane microdomains are recruited into early endosomes from where they can become incorporated into multivesicular body (MVB), which migrate towards and fuse with the cell membrane releasing invaginated endosomes as exosomes.
PRODUCT DETAILS
Clone: 2D9/TSPAN8
Antibody Type: Monoclonal
Reactivity: Rat
Format: PE
Host: Mouse
Isotype: IgG2a, κ
Applications: FC - Quality tested
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
Original: $167.00
-70%$167.00
$50.10PE anti-rat TSPAN8
Tetraspanins, also referred to as the transmembrane 4 superfamily (TM4SF) proteins, have four transmembrane alpha-helices and two extracellular domains. It acts as molecular facilitators forming a web between themselves and a multitude of molecules. It is also involved in adhesion, motility, matrix modulation and cell fusion. Tetraspanins/Tetraspanin-complexes are constitutive components of exosomes. During exosome assembly, Tetraspanins become internalized via a tyrosine-based internalization motif. Internalized membrane microdomains are recruited into early endosomes from where they can become incorporated into multivesicular body (MVB), which migrate towards and fuse with the cell membrane releasing invaginated endosomes as exosomes.
PRODUCT DETAILS
Clone: 2D9/TSPAN8
Antibody Type: Monoclonal
Reactivity: Rat
Format: PE
Host: Mouse
Isotype: IgG2a, κ
Applications: FC - Quality tested
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
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Description
Tetraspanins, also referred to as the transmembrane 4 superfamily (TM4SF) proteins, have four transmembrane alpha-helices and two extracellular domains. It acts as molecular facilitators forming a web between themselves and a multitude of molecules. It is also involved in adhesion, motility, matrix modulation and cell fusion. Tetraspanins/Tetraspanin-complexes are constitutive components of exosomes. During exosome assembly, Tetraspanins become internalized via a tyrosine-based internalization motif. Internalized membrane microdomains are recruited into early endosomes from where they can become incorporated into multivesicular body (MVB), which migrate towards and fuse with the cell membrane releasing invaginated endosomes as exosomes.
PRODUCT DETAILS
Clone: 2D9/TSPAN8
Antibody Type: Monoclonal
Reactivity: Rat
Format: PE
Host: Mouse
Isotype: IgG2a, κ
Applications: FC - Quality tested
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
