PE anti-mouse DCIR4 (Clec4a1)
Clec4a1 or dendritic cell inhibitory receptor 4 (DCIR4) is a C-type lectin receptor (CLR) which belongs to DC immunoreceptor (DCIR) family. Inhibitory members of DCIR family are type II membrane glycoprotein consisting of a carbohydrate recognition domain (CDR) on their COOH terminus and immunoreceptor tyrosin-based inhibitory motifs (ITIM) on their intracellular domain. Studies indicate that inhibitory DCIRs play an anti-inflammatory role and that immunopathology related to rheumatoid arthritis and TB infection is driven by their loss. Inhibitory DCIR are found on DCs, B cells, monocytes, macrophages, and neutrophils, but not T or NK cells and relay signal through Src homology region 2 domain-containing phosphatase (SHP). DCIR4, yet to be confirmed to have inhibitory role, is exclusive to non-granulocytic myeloid cells and its expression level can be used to differentiate between patrolling and inflammatory monocytes.
PRODUCT DETAILS
Clone: MH7E7
Antibody Type: Monoclonal
Reactivity: Mouse
Format: PE
Host: Rat
Isotype: IgG1, κ
Applications: FC - Quality tested
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
Original: $168.00
-70%$168.00
$50.40PE anti-mouse DCIR4 (Clec4a1)
Clec4a1 or dendritic cell inhibitory receptor 4 (DCIR4) is a C-type lectin receptor (CLR) which belongs to DC immunoreceptor (DCIR) family. Inhibitory members of DCIR family are type II membrane glycoprotein consisting of a carbohydrate recognition domain (CDR) on their COOH terminus and immunoreceptor tyrosin-based inhibitory motifs (ITIM) on their intracellular domain. Studies indicate that inhibitory DCIRs play an anti-inflammatory role and that immunopathology related to rheumatoid arthritis and TB infection is driven by their loss. Inhibitory DCIR are found on DCs, B cells, monocytes, macrophages, and neutrophils, but not T or NK cells and relay signal through Src homology region 2 domain-containing phosphatase (SHP). DCIR4, yet to be confirmed to have inhibitory role, is exclusive to non-granulocytic myeloid cells and its expression level can be used to differentiate between patrolling and inflammatory monocytes.
PRODUCT DETAILS
Clone: MH7E7
Antibody Type: Monoclonal
Reactivity: Mouse
Format: PE
Host: Rat
Isotype: IgG1, κ
Applications: FC - Quality tested
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
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Description
Clec4a1 or dendritic cell inhibitory receptor 4 (DCIR4) is a C-type lectin receptor (CLR) which belongs to DC immunoreceptor (DCIR) family. Inhibitory members of DCIR family are type II membrane glycoprotein consisting of a carbohydrate recognition domain (CDR) on their COOH terminus and immunoreceptor tyrosin-based inhibitory motifs (ITIM) on their intracellular domain. Studies indicate that inhibitory DCIRs play an anti-inflammatory role and that immunopathology related to rheumatoid arthritis and TB infection is driven by their loss. Inhibitory DCIR are found on DCs, B cells, monocytes, macrophages, and neutrophils, but not T or NK cells and relay signal through Src homology region 2 domain-containing phosphatase (SHP). DCIR4, yet to be confirmed to have inhibitory role, is exclusive to non-granulocytic myeloid cells and its expression level can be used to differentiate between patrolling and inflammatory monocytes.
PRODUCT DETAILS
Clone: MH7E7
Antibody Type: Monoclonal
Reactivity: Mouse
Format: PE
Host: Rat
Isotype: IgG1, κ
Applications: FC - Quality tested
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
