Cellular Senescence Kit Red
Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide and do not respond to growth-promoting stimuli. It is triggered by a variety of cellular stressors, including environmental factors like ionizing radiation or exposure to chemotherapeutic drugs, oxidative stress, DNA damage, mitochondrial dysfunction, and oncogene activation. Senescence-Associated β-galactosidase (SA-β-gal), a result of altered lysosomal activity, is a hallmark of cellular senescence. Cellular Senescence Kit Red uses a fluorogenic beta-Gal substrate that readily enters into live cells, where it gets cleaved by SA-β-gal inside cells, generating strong red fluorescence. It provides higher sensitivity compared to X-gal staining, a colorimetric method widely available and used to detect Senescence-associated beta-galactosidase (SA-beta-gal) in senescent cells.
PRODUCT DETAILS
Clone: None
Antibody Type: None
Reactivity: Mouse, Human
Format: None
Host: None
Isotype: None
Applications: FC - Quality tested Live cell imaging - Verified
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
Original: $718.00
-70%$718.00
$215.40Cellular Senescence Kit Red
Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide and do not respond to growth-promoting stimuli. It is triggered by a variety of cellular stressors, including environmental factors like ionizing radiation or exposure to chemotherapeutic drugs, oxidative stress, DNA damage, mitochondrial dysfunction, and oncogene activation. Senescence-Associated β-galactosidase (SA-β-gal), a result of altered lysosomal activity, is a hallmark of cellular senescence. Cellular Senescence Kit Red uses a fluorogenic beta-Gal substrate that readily enters into live cells, where it gets cleaved by SA-β-gal inside cells, generating strong red fluorescence. It provides higher sensitivity compared to X-gal staining, a colorimetric method widely available and used to detect Senescence-associated beta-galactosidase (SA-beta-gal) in senescent cells.
PRODUCT DETAILS
Clone: None
Antibody Type: None
Reactivity: Mouse, Human
Format: None
Host: None
Isotype: None
Applications: FC - Quality tested Live cell imaging - Verified
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
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Description
Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide and do not respond to growth-promoting stimuli. It is triggered by a variety of cellular stressors, including environmental factors like ionizing radiation or exposure to chemotherapeutic drugs, oxidative stress, DNA damage, mitochondrial dysfunction, and oncogene activation. Senescence-Associated β-galactosidase (SA-β-gal), a result of altered lysosomal activity, is a hallmark of cellular senescence. Cellular Senescence Kit Red uses a fluorogenic beta-Gal substrate that readily enters into live cells, where it gets cleaved by SA-β-gal inside cells, generating strong red fluorescence. It provides higher sensitivity compared to X-gal staining, a colorimetric method widely available and used to detect Senescence-associated beta-galactosidase (SA-beta-gal) in senescent cells.
PRODUCT DETAILS
Clone: None
Antibody Type: None
Reactivity: Mouse, Human
Format: None
Host: None
Isotype: None
Applications: FC - Quality tested Live cell imaging - Verified
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
