CD119 (IFN gamma Receptor 1) Monoclonal Antibody (GR-20), Functional Grade, eBioscience

PRODUCT DETAILS

Host: Rat

Isotype: IgG2a, kappa

Clonality: Monoclonal

Clone: GR-20

Format: Functional Grade

Reactivity: Ms

Application: Flow Cytometry

Tested Dilution: Assay-Dependent

Concentration: 1 mg/mL

Storage: 4°C

Formulation: PBS with no preservative; pH 7.2

Purification: Affinity chromatography

Data Sheet: TDS

Specific Information

Description: The monoclonal antibody GR-20 recognizes mouse CD119 also known as IFN gamma receptor 1. CD119 heterodimerizes with IFN gamma receptor 2 (AF-1) forming the Class II cytokine receptor. The ligand IFN gamma binds IFN gamma receptor 1 subunit but signal transduction transpires via the IFN gamma receptor 2 subunit. The receptor is involved in host defense and expression is broad including B cells, NK cells, macrophages and dendritic cells as well as other non-hematopoietic cell types. The GR-20 antibody has been reported to block IFN gamma binding to CD119.

Applications Reported: This GR-20 antibody has been reported for use in flow cytometric analysis and functional assays (blocking cytokine binding to the receptor).

Storage and handling: Use in a sterile environment.

Filtration: 0.2 µm post-manufacturing filtered.

Purity: Greater than 90%, as determined by SDS-PAGE.

Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.

Aggregation: Less than 10%, as determined by HPLC.

 

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.