Alexa Fluor® 647 anti-DBN1
Drebrin (DBN1) is an actin-binding protein that was identified as a developmentally regulated protein expressed in the brain. Drebrin interacts with microtubules and is localized to focal adhesions, adherens junctions, gap junctions, immunological synapses, and neuronal synapses to modulate cellular processes such as cell migration, cell process formation, cancer metastasis, and spermatogenesis. There are two isoforms of mammals as a result of alternative splicing: Drebrin A (adult) and Drebrin E (embryonic). The expression of Drebrin A is highly specific to neurons and regulates the reorganization of actin filaments and thus contributes to memory, whereas Drebrin E is expressed in various tissues. Studies have shown that a decrease in the amount of Drebrin protein in the brain is thought to be a factor contributing to the pathogenesis of dementia in Alzheimer's disease (AD), Down syndrome (DS), and bipolar disorder (BD).
PRODUCT DETAILS
Clone: W21139F
Antibody Type: Monoclonal
Reactivity: Human
Format: DBN1
Host: Rat
Isotype: IgG2b, κ
Applications: ICC - Quality tested ICFC - Verified
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
Original: $188.00
-70%$188.00
$56.40Alexa Fluor® 647 anti-DBN1
Drebrin (DBN1) is an actin-binding protein that was identified as a developmentally regulated protein expressed in the brain. Drebrin interacts with microtubules and is localized to focal adhesions, adherens junctions, gap junctions, immunological synapses, and neuronal synapses to modulate cellular processes such as cell migration, cell process formation, cancer metastasis, and spermatogenesis. There are two isoforms of mammals as a result of alternative splicing: Drebrin A (adult) and Drebrin E (embryonic). The expression of Drebrin A is highly specific to neurons and regulates the reorganization of actin filaments and thus contributes to memory, whereas Drebrin E is expressed in various tissues. Studies have shown that a decrease in the amount of Drebrin protein in the brain is thought to be a factor contributing to the pathogenesis of dementia in Alzheimer's disease (AD), Down syndrome (DS), and bipolar disorder (BD).
PRODUCT DETAILS
Clone: W21139F
Antibody Type: Monoclonal
Reactivity: Human
Format: DBN1
Host: Rat
Isotype: IgG2b, κ
Applications: ICC - Quality tested ICFC - Verified
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
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Description
Drebrin (DBN1) is an actin-binding protein that was identified as a developmentally regulated protein expressed in the brain. Drebrin interacts with microtubules and is localized to focal adhesions, adherens junctions, gap junctions, immunological synapses, and neuronal synapses to modulate cellular processes such as cell migration, cell process formation, cancer metastasis, and spermatogenesis. There are two isoforms of mammals as a result of alternative splicing: Drebrin A (adult) and Drebrin E (embryonic). The expression of Drebrin A is highly specific to neurons and regulates the reorganization of actin filaments and thus contributes to memory, whereas Drebrin E is expressed in various tissues. Studies have shown that a decrease in the amount of Drebrin protein in the brain is thought to be a factor contributing to the pathogenesis of dementia in Alzheimer's disease (AD), Down syndrome (DS), and bipolar disorder (BD).
PRODUCT DETAILS
Clone: W21139F
Antibody Type: Monoclonal
Reactivity: Human
Format: DBN1
Host: Rat
Isotype: IgG2b, κ
Applications: ICC - Quality tested ICFC - Verified
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
