Alexa Fluor® 488 anti-Galectin-7
The galectins are a family of beta-galactoside-binding proteins implicated in cell-cell and cell-matrix interactions. Galectin-7 is specifically expressed in stratified epithelia and epidermis, but barely detected in epidermal tumors and absent from squamous carcinoma cell lines. Galectin-7 is a p53-induced protein and is abnormally expressed in variety of tumors such as melanoma, lung cancer and colon cancer. In UVB-induced sunburn keratinocytes, the expression of Galectin-7 is markedly increased due to the genotoxic stress-induced p53 activation. Both positive and negative regulatory roles of Galectin-7 have been reported in tumorigenesis.
PRODUCT DETAILS
Clone: A18059A
Antibody Type: Monoclonal
Reactivity: Human, Mouse
Format: Alexa Fluor 488
Host: Rat
Isotype: IgG2a, κ
Applications: IHC-P - Quality tested
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
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Alexa Fluor® 488 anti-Galectin-7
The galectins are a family of beta-galactoside-binding proteins implicated in cell-cell and cell-matrix interactions. Galectin-7 is specifically expressed in stratified epithelia and epidermis, but barely detected in epidermal tumors and absent from squamous carcinoma cell lines. Galectin-7 is a p53-induced protein and is abnormally expressed in variety of tumors such as melanoma, lung cancer and colon cancer. In UVB-induced sunburn keratinocytes, the expression of Galectin-7 is markedly increased due to the genotoxic stress-induced p53 activation. Both positive and negative regulatory roles of Galectin-7 have been reported in tumorigenesis.
PRODUCT DETAILS
Clone: A18059A
Antibody Type: Monoclonal
Reactivity: Human, Mouse
Format: Alexa Fluor 488
Host: Rat
Isotype: IgG2a, κ
Applications: IHC-P - Quality tested
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
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Description
The galectins are a family of beta-galactoside-binding proteins implicated in cell-cell and cell-matrix interactions. Galectin-7 is specifically expressed in stratified epithelia and epidermis, but barely detected in epidermal tumors and absent from squamous carcinoma cell lines. Galectin-7 is a p53-induced protein and is abnormally expressed in variety of tumors such as melanoma, lung cancer and colon cancer. In UVB-induced sunburn keratinocytes, the expression of Galectin-7 is markedly increased due to the genotoxic stress-induced p53 activation. Both positive and negative regulatory roles of Galectin-7 have been reported in tumorigenesis.
PRODUCT DETAILS
Clone: A18059A
Antibody Type: Monoclonal
Reactivity: Human, Mouse
Format: Alexa Fluor 488
Host: Rat
Isotype: IgG2a, κ
Applications: IHC-P - Quality tested
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.
